欧洲疾控中心：2025年在非艾滋病毒免疫功能低下个体中，HPV疫苗接种的疗效、效果、免疫原性和安全性系统评价和荟萃分析报告（英文版）

Cervical cancer is the fourth most common cancer affecting women worldwide. It is caused by persistent infection with oncogenic types of human papillomavirus (HPV). More than 200 types of HPV have been identified and more than 40 types of them infect the genital tract. HPV 16 and 18 are the two primary oncogenic types and responsible for 77% of cervical cancers (i.e. squamous cell carcinoma), and combined with HPV 31, 33, 45, 52 and 58, account for 94.9% of cervical cancers [1-3]. While HPV i