Citeline：2025年抗体药物偶联物：“神奇子弹”成为现实白皮书（英文版）

ADCs consist of three components: an antibody, a linker, and a payload. An antibody against a tumor antigen acts as a targeted delivery system, guiding the ADC directly towards antigen-expressing tumor cells, avoiding toxicity to healthy cells and unwanted side effects. Target selection is crucial to the effectiveness of ADCs, and those preferentially or exclusively expressed at high levels on the surface of tumor cells make the best targets. In terms of antibody selection, current ADCs are w